comparison of the levels of tumor necrosis factor-α and interleukin-17 in gingival crevicular fluid of patients with peri-implantitis and a control group with healthy implants.
نویسندگان
چکیده
peri-implantitis is a multi-factorial disease involving peri-implant tissues and resulting in therapeutic failure. inflammatory mediators and cytokines in the gingival crevicular fluid (gcf) have pivotal roles in the disease pathogenesis and could be used for disease monitoring. therefore, the present study was conducted to compare the gcf levels of tnf-α and il-17 between patients with peri-implantitis and healthy implants. in this case-control study, 24 patients with peri-implantitis and 18 individuals with healthy implants referring to faculty of dentistry in tehran university of medical sciences were selected. gcf was collected by paper cons number 30. samples were preserved in pbs -70ºc. tnf-α and il-17 levels in gcf were determined by elisa method. data were analyzed by spss software version 13, using descriptive indices and independent t tests. mean probing depth in peri-implantitis and control groups were 6.2 ± 1.1 and 3.7 ± 1.6 mm respectively. mean level of il-17 in patients with peri-implantitis was significantly more than the control group (19.8 ± 16.0 versus 9.3 ± 8.4 pg per site in 40 seconds, p=0.016). also, mean level of tnf-α in patients with peri-implantitis was more than control group (39.0 ± 3.9 versus 14.5 ± 9.0 pg per site in 40 seconds, p =0.000). the significant higher levels of tnf-α and il-17 in patients with peri-implantitis compared to control group indicated the pivotal role of these cytokines in peri-implantitis and could be suggested as diagnostic markers and in future possibly for immunomodulatory treatments.
منابع مشابه
Comparison of the levels of tumor necrosis factor-α and interleukin-17 in gingival crevicular fluid of patients with peri-implantitis and a control group with healthy implants.
Peri-implantitis is a multi-factorial disease involving peri-implant tissues and resulting in therapeutic failure. Inflammatory mediators and cytokines in the Gingival Crevicular Fluid (GCF) have pivotal roles in the disease pathogenesis and could be used for disease monitoring. Therefore, the present study was conducted to compare the GCF levels of TNF-α and IL-17 between patients with peri-im...
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15 صفحه اولcomparison of interleukin-1β levels in gingival crevicular fluid and peri-implant crevicular fluid and its relationship with clinical indexes.
interleukin-1β (il-1β) is one of the most important cytokines which seems to have an important role in the inflammatory process in gingival and peri-implant tissues. the aim of this split-mouth study was to investigate the relationship between the concentration of il-1β in gingival crevicular fluid (gcf) and peri-implant crevicular fluid (picf) and clinical parameters such as plaque index (pi),...
متن کاملEffects of Non-Surgical Periodontal Therapy on Gingival Crevicular Fluid Levels of Interleukin-17 and Interleukin-23 in Patients with Periodontitis: A Clinical Trial
Background and Aim: Considering the critical role of inflammatory responses in periodontal disease, knowledge about the immune system and cytokines seems nec-essary. The aim of this study was to evaluate the level of IL-23 and IL-17 in gingival crevicular fluid (GCF) of patients with chronic and aggressive periodontitis, before and after non-surgical periodontal therapy. Materials and Methods:...
متن کاملComparison of Interleukin-1β Levels in Gingival Crevicular Fluid and Peri-Implant Crevicular Fluid and Its Relationship with Clinical Indexes
OBJECTIVE Interleukin-1β (IL-1β) is one of the most important cytokines which seems to have an important role in the inflammatory process in gingival and peri-implant tissues. The aim of this split-mouth study was to investigate the relationship between the concentration of IL-1β in gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) and clinical parameters such as plaque i...
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عنوان ژورنال:
iranian journal of allergy, asthma and immunologyجلد ۱۲، شماره ۱، صفحات ۷۵-۸۰
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